منابع مشابه
Shapes of MHC Restriction Review structures of a TCR b subunit and a
face of the molecule. A fourth loop, termed HV4, is also † Molecular Immunology Section present. The exception to these similarities has been Neuroimmunology Branch the C domain of the ␣ chain that has a noncanonical National Institute of Neurological Disorders fold (Garcia et al., 1996; Ding et al., 1998). Structural and Stroke studies of entire ␣TCR molecules were slowed by the National Inst...
متن کاملMHC restriction and allogeneic immune responses.
Discovery of major histocompatability complex (MHC) restriction helped in the understanding of how T-lymphocytes recognize antigens on bacteria, viruses, and tumor cells. It was initially accepted that MHC restriction was a consequence of "adaptive differentiation" in the thymus; during differentiation, the forming repertoire of T-lymphocytes "learned" a low affinity for self MHC molecules via ...
متن کاملPutting a face to MHC restriction.
It is now an immunological fact that small peptides bound to polymorphic MHC molecules are the antigenic ligands recognized by TCRs. All of protective immunity is built from and fueled by these interactions, as are the chronic diseases of autoimmunity and hypersensitivity that afflict affluent society. Through positive and negative selection in the thymus, self peptides bound to autologous MHC ...
متن کاملMHC Restriction of V-V Interactions in Serum IgG
is based on Jerne’s hypothesis, and provides a basis for understanding many of the phenomena of adaptive immunity. The theory includes the postulate that the repertoire of serum IgG molecules is regulated by T cells, with the result that IgG molecules express V region determinants that mimic V region determinants present on suppressor T cells. In this paper we describe rapid binding between pur...
متن کاملFine specificity and MHC restriction of trinitrophenyl-specific CTL.
In this study, the fine specificity and MHC restriction of a CTL response specific to the trinitrophenyl (TNP) hapten was analyzed. Based on the structure of peptide/Kb complexes and ternary TCR/Ag/MHC complexes, four TNP peptides, two octamers, and two nonamers were chosen for eliciting anti-TNP CTL responses. Hapten was conjugated at position 4 in the octamers and at position 5 in the nonamer...
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ژورنال
عنوان ژورنال: Immunity
سال: 1999
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(00)80001-1